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KMID : 0812020060120020127
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Korean Journal of Neurogastroenterology and Motility
2006 Volume.12 No. 2 p.127 ~ p.135
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The Effect of Lactulose on the Colon Transit and the Various Symptoms of Constipation in Patients with Functional Constipation
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Lee Joon-Seong
Kim Yong-Dae
Im Hee-Hyuk
Jung In-Seop
Ko Bong-Min
Hong Su-Jin
Ryu Chang-Beom
Kim Jin-Oh
Cho Joo-Young
Lee Moon-Sung
Shim Chan-Sup
Kim Boo-Sung
Jo Young-Man
Choi Deuk-Lin
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Abstract
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Background/Aims: We wanted to evaluate the effect of lactulose on the various symptoms of constipation and colon transit in patients suffering with functional constipation.
Methods: Colon transit was measured by scintigraphy before and 1 week after lactulose treatment (45-60 ml/day) in 15 female patients with functional constipation. The frequency and severity of constipation symptoms were
measured by using an ordinary scale and daily diaries.
Results: There was no significant difference in the geometric centers before and after treatment. Only the t1/2 of the proximal colon tended to be shortened after treatment. In 5 patients with slow transit constipation, lactulose accelerated colonic transit at 48 hours (GC48: 2.6±0.6 vs. 3.4±1.0, p<0.05) and there was reduction of the t1/2 for proximal colonic emptying (63.5±23.2 h vs. 38.9±20.1 h, p<0.05). Lactulose increased stool frequency (3.8±1.3/wk vs. 6.9±3.3/wk, p<0.05),
changed the form of the stool (p<0.05), facilitated passage of stool (p<0.01), and improved the frequency and severity of straining, the sensation of anorectal obstruction and the sensation of incomplete evacuation in 15 constipated patients (p<0.05).
Conclusions: Lactulose improved most of the constipation symptoms in the patients suffering with functional constipation. In the patients with slow transit constipation, these improvements of symptoms may be due to acceleration of the proximal colonic transit via lactulose. (Kor J Neuro-gastroenterol Motil 2006;12:127-135)
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KEYWORD
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Laculose, Constipation, Colon transit, Scintingraphy
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